Aug 14, 2019
The NCI is implementing a program intended to connect and closely coordinate the Division of Cancer Treatment and Diagnosis' (DCTD's) immunotherapeutics and other drug development activities with the translational oriented clinical trials of the Center for Cancer Research's (CCR's) Comparative Oncology Program (COP), especially the treatment of dogs with natural occurring cancers that can inform the prioritization of DCTD's clinical trial portfolio and elucidate drug mechanisms of action that cannot be studied readily in human patient populations. COP is launching a pilot program aimed to develop and oversee a series of comparative oncology Phase 0 studies, which assess novel anti-cancer agents in naturally-occurring canine cancers. The pilot program will be undertaken in collaboration with the DCTD through the existing Comparative Oncology Trials Consortium (COTC) infrastructure. KEY ROLES/RESPONSIBILITIES This position description does not represent a current opening but may be used to identify candidates with skills and experience for positions within Leidos Biomedical Research that frequently become available. Candidates who express an interest may be considered for future positions at Leidos Biomedical Research. Review, analyze and interpret laboratory animal pharmacology, toxicology and preclinical modelling/efficacy data provided by the DCTD Provide protocol and SOP authorship inclusive of literature review, including design of canine clinical trials with input from COP leadership and toxicology, pharmacology, and assay development groups within the DCTD Demonstrate and maintain proficiency with the Oracle C3D database for all data management tasks, but will also be responsible for maintenance of CCR Clinical Informatics Wiki sites and other applicable Excel spreadsheets Review, analyze and interpret all data (clinical response, hematology, biochemistry, imaging, etc.) Generated in comparative canine clinical trials Provide monthly oral presentation of data via PowerPoint slides to COP and DCTD leadership Be responsible for direct, daily communications with COTC membership regarding protocol training and provision of protocol amendments, questions regarding canine patient management/adverse event management Conduct monthly interviews via telephone with all canine clinical trial sites to verify entry and determine the attribution of all efficacy and toxicity data reported in C3D Author quarterly study reports, submitted to study sponsors and COP leadership Co-author manuscripts that result from for canine clinical trials, inclusive of manuscript writing, literature review, creation of figures/data tables Conduct laboratory studies to elucidate a deeper understanding of key questions that arise during these trials BASIC QUALIFICATIONS Possession of a Doctor of Veterinary Medicine (DVM) or Veterinariae Medicinae Doctoris (VMD) degree from an AVMA (American Veterinary Medical Association) accredited college or university according to the Council for Higher Education Accreditation. Foreign degrees must be evaluated for U.S. equivalency Must have completed a residency in an American College of Veterinary Internal Medicine (ACVIM) or American College of Veterinary Radiology (ACVR)-approved program In addition to the educational requirements, a minimum of eight (8) years of experience including 3 years in veterinary oncology or related field Must be able to obtain and maintain a security clearance Have specialized expertise: in canine cancers and their treatment; in the design, conduct and management of canine clinical trials; and in the conduct of translational laboratory experimentation Equal Opportunity Employer (EOE) | Minority/Female/Disabled/Veteran (M/F/D/V) | Drug Free Workplace (DFW)
Frederick National Laboratory for Cancer Research
Bethesda, MD, USA